Most recently, with genetic testing, my husband has been found to have both MTHFR gene mutations (A1298C +/- and C677T +/-) as well and he too needs supplementation with methylfolate. With my husband affected with MTHFR....and me, affected with DHFR, it is no wonder my kids have problems with breaking down folic acid and detoxifying. In fact, my daughter with autism has a MTHFR A1298C (+/-) gene mutation, several DHFR (+/-) gene mutations among many other mutations that affect methylation pathways.
#5 - Most importantly....please know that this mutation makes detoxification difficult for the body. So, go green and keep toxins away!
Many of you have asked how taking methylfolate with methyl B12 has helped my daughter. This was not an over-night "wow". It takes some time for the folate to build up to an acceptable level in the body. We saw slow and steady gains with speech and cognition and socialization. I see more irritability in her little sister when she does not get her methylfolate and B12 in the morning.
MTHFR C677T and A1298C polymorphisms and cerebral stroke in two twin gestations.Childs Nerv Syst. 2011 Apr;27(4):665-9. Epub 2010 Nov 27. http://www.ncbi.nlm.nih.gov/pubmed/21113717
J Matern Fetal Neonatal Med. 2012 Feb;25(2):133-7. Epub 2011 Mar 28.http://www.ncbi.nlm.nih.gov/pubmed/21443409
Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability?
Brain Behav Immun. 2011 Nov;25(8):1530-43. Epub 2010 Dec 24. http://www.ncbi.nlm.nih.gov/pubmed/21185933